![]() PMID 18174752 A cascade of epigenetic events contributes to the selective growth advantage of cancer cells during tumor progression. Re-expression of 15-LOX-1 in colon cancer cells can function as an important therapeutic mechanism and could be further exploited to develop novel treatment approaches for this common cancer. The transcriptional repression of 15-LOX-1 in colon cancer cells is complex and involves multiple mechanisms (e.g., histone methylation, transcriptional repressor binding). These data indicate that 15-LOX-1 promotes various anti-tumorigenic events, including cell differentiation and apoptosis, and inhibits chronic inflammation, angiogenesis, and metastasis. Emerging data support a tumor suppressor role for 15-LOX-1, especially in colon cancer. 15-LOX-1 is downregulated in human colorectal polyps and cancers. 15-LOX-1 significantly contributes to the resolution of inflammation and to the terminal differentiation of normal cells. PMID 22037943 15-Lipoxygenase-1 (15-LOX-1) is an inducible and highly regulated enzyme in normal human cells that plays a key role in the production of lipid signaling mediators, such as 13-hydroxyoctadecadienoic acid (13-HODE) from linoleic acid. ![]() ![]() Genes are in ORANGE, Diseases are in RED, and methylation words are in GREEN.ฤก. ![]() Sentences that are used for the system are in BOLD. Benchmarking Dataset for Building and Testing the Models
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